From Plasma to Products: Various Human Plasma Solutions

Blood is a real lifesaving bodily fluid— not only for people who have an ample volume of healthy blood flowing through their veins, but also for those who have lost so much and now in desperate need of clean blood that could ultimately save their lives and help them regain their strength and energy.

Aside from the common knowledge about blood donation (one person gives his/her own blood to a licensed institution, then that blood will be transfused to another person who needs it), the human blood given in donations is also used in developing, creating, and manufacturing various therapies and medicines— specifically its dominating component, which is plasma.

Plasma, the clear liquid which makes up 55% of the human blood, has been— and is still being— used for several lifesaving medications. In this article, you will discover what these products are and their benefits to those ailing people who need immediate and guaranteed recovery.



Plasma, when extracted from the body, can serve many purposes. Once out of the system and into the bag, it is broken down into important substances that will eventually lead to three plasma product types: immunoglobulins, human albumin solutions, and coagulation factors.


Immunoglobulins are essential antibodies that are part of the immune system, which is, as we all know, is the body’s natural defense against all kinds of diseases and illnesses. They are the ones responsible for warding off various infections, viruses, and bacteria.

These components are divided into two parts: specific and non-specific.

Specific immunoglobulins are often used to develop products that are given to patients who have been exposed to certain infections. Some examples of products derived from specific immunoglobulins are the antidotes to rabies, hepatitis B, tetanus, and chickenpox. The anti-D immunoglobulin, a product which is given to rhesus-negative (RhD negative) pregnant women to prevent them from becoming sensitive to their baby’s blood, is also a perfect example of a specific immunoglobulin product.

Non-specific immunoglobulins are often used for people who are having problems producing their own antibodies. Whether by birth or because of certain treatments (which make them incapable of making good antibodies), some people need non-specific immunoglobulins to make up for their faulty immune system.

Human albumin solutions

Albumin is an important component of plasma. It is responsible for cleaning the blood, maintaining the right amount of fluid around the body, and carrying vital substances in the body. It is also the dominant protein in plasma.

Solutions made out of human albumin are helpful in treating various illnesses and accidents, such as:

  • liver disease
  • kidney disease
  • burns
  • sepsis
  • incorrect level of body circulation

Coagulation factors

Coagulation (or clotting) factors are plasma proteins that function with platelets to clot blood. They aid in controlling bleeding and ensure that the blood clots properly.

Clotting factors can be used for treatments concerning bleeding/blood clotting disorders, such as hemophilia. People with this kind of illness can be treated with replacement therapy, wherein it will replace a certain missing clotting factor.



Aside from the three main types— and the products that can be derived from them— mentioned, there are other products that were made possible by plasma.

Heparin anticoagulant

Heparin is an anticoagulant substance that is used to prevent blood clot formation during or after a certain surgery. It is also used as a treatment for different circulatory, lung, and heart disorders with a higher risk of blood clot formation.

Antihemophilic Factor

Like clotting factors, antihemophilic factors are used to aid proper blood clotting. It is put inside the body either by vein injection or addition in an intravenous fluid that will drip through a needle in your vein.

Anti-Inhibitor Coagulant Complex

Like other plasma products, the anti-inhibitor coagulant complex is used to control bleeding, especially in patients with hemophilia A and B during surgery. It has vital substances that help the blood clot and stop bleeding. It can be given by means of powder for solution.

Antithrombin (Recombinant)

A recombinant antithrombin is used to prevent perioperative and peripartum thromboembolic events in patients with hereditary antithrombin deficiency. Its function is to regulate the inflammatory process and blood clotting.


Corifact is an FXIII concentrate that is used for routine prophylactic treatment and perioperative management of bleeding in surgeries for adults. It is also intended for patients with congenital FXIII deficiency.

Kcentra (Prothrombin Complex Concentrate, Human)

Kcentra is used for acute major bleeding therapies, urgent surgery cases, and immediate reversal of coagulation factor deficiency received by a patient.

Protein C Concentrate (Human)

Protein C Concentrate is used for treatment and possible prevention of purpura fulminans and venous thrombosis in patients who suffer from congenital Protein C deficiency. It is also used as a replacement therapy for treatment of warfarin-induced skin necrosis that is acquired during oral anticoagulation.


Medicines and injectable proteins are not the only beneficial things that indirect recipients of your plasma could be thankful for. Another product that can be developed out of the plasma in your body is fresh, frozen plasma.

So, how does this work?

When you donate blood, a special machine will process it and separate the plasma from your blood. Then, it will be frozen and stored until a patient that requires a plasma transfusion comes along. When that happens, your fresh, frozen plasma will be thawed under controlled conditions and will be transfused to that patient who is in need of your lifesaving plasma.

Frozen plasma is intended for multiple reasons/medical cases, such as:

  • multiple coagulation factor replacement for patients who suffer from liver disease deficiencies
  • replacement therapy for patients undergoing liver transplant or cardiac surgery
  • plasma exchange with patients who have thrombotic thrombocytopenic purpura (TTP)
  • treatment of bleeding that is caused by multiple factor deficiencies
  • treatment of people with coagulation factor deficiencies
  • treatment of patients with rare plasma protein deficiencies
  • replacement of labile clotting factors and other proteins


Plasma is a very helpful component. Once transfused to a patient’s body, it will serve a very good purpose. But, be careful with the side effects. Some of the harmful effects of plasma transfusion are acute lung injury, haemolysis, anaphylactic and allergic reactions, and even the dreaded Creutzfeldt-Jakob disease. Consult your doctor very well before a plasma transfusion.

Stories of Plasma Heroes

In medical terms, when we come across the word “donate,” the first thing that comes in our minds is whole blood donation. To the untrained and unfamiliar eye, it may seem as if full blood is being donated all the time. The truth is, most of the time, it is not.

Aside from whole blood donation, people also give blood components individually, such as platelets, red blood cells, white blood cells, and of course, plasma. In this article, we are going to focus more on the latter component, which is mainly what makes up blood itself.



First of all, what is this thing we call plasma?

Actually, the human blood is composed mostly of plasma, taking up 55% of it. It is a clear, pale yellow liquid that contains important antibodies, proteins, enzymes, and salts that are essential to the overall good health of the body.

Plasma regenerates faster than blood, so donors of this component are free to donate as often as twice a week— which is, of course, after they have gotten enough rest of about 48 hours.



Being a known component of blood, plasma is regarded for its importance and contribution to the medical field. The elements found in plasma are proven to have great benefits to people who are suffering from various illnesses or psychological damage.

Plasma protein therapies (PPTs) are great examples of how helpful plasma is. These therapies are developed from human genes, and can aid in several medical treatments, such as:

  • Burn, shock or trauma (human serum albumin)
  • Hepatitis, rabies/tetanus, fetal complications (hyperimmune globulin)
  • Blood clotting
  • Hemophilia
  • Antithrombin deficiency



Donating plasma sounds like— and totally is— a good thing. More people should consider giving some of their plasma to those who truly need it.

But, as much as hospitals and blood banks want more plasma, there are still limitations as to who should donate plasma… and who should not.

Also, the volume of plasma to be donated should also be monitored. Even though plasma rebuilds inside the body quickly, the amount to be given should still be controlled.

Donor limitations

The age limit for potential blood donors is 17 years old (minimum) and 69 years old (maximum), though it varies in some states and countries. In other areas, there is no maximum age limit for plasma donors and 16 year-old teenagers are allowed to donate— as long as they have a parental consent.

The donor’s weight is also important in plasma donation. The limit is 110 pounds (minimum), and this is the general weight rule in most places.

Other limitations include those concerning unfit lifestyle (tattoos, piercings, etc.), medical history, travel history, and current health state.

Plasma limitations

While it will be good to the society to have abundance in the supply of plasma, there are still some limitations to donating this blood component.

First of all, donors should not give plasma more than two times a week— especially for frequent plasmapheresis, or the process of separating plasma from the blood. There should also be a 48-hour interval between donations, which means that you cannot donate for two consecutive days. This adds up to a total of 104 plasma donations in a year.

There is also a maximum limit as to how much plasma a donor can give. According to the US Food and Drug Administration or FDA, the collection volume of donated plasma varies, depending on the donor’s weight.

Here is a more specific basis, with the anticoagulant volume included in the total collection volume of each weight:

  • 10-149 pounds -> 625 mL (plasma volume) -> 690 mL (collection volume)
  • 150-174 pounds -> 750 mL (plasma volume) -> 825 mL (collection volume)
  • 175 pounds and above -> 800 mL (plasma volume) -> 880 mL (collection volume)



Despite of all the safety measures that hospitals and blood banks implement to carefully select who among the world’s population can donate plasma, there are still many kindred spirits who pass the tests and screenings.

The best part is, there are people who go out of their ways to prove that they can be heroes on their own rights. These are the people who exceed expectations— and plasma donation count.

Richard Burke

On June 2004, Burke set a new record when he donated his 1,411th unit of blood and made his 1,193rd blood donation.

Burke started donating in 1975, and since then, he has been doing apheresis— which is the process of separating certain components of the blood from itself.

He still holds the title until now, with an equivalent of 634.95 liters of blood donated.

James Harrison

Dubbed as the “man with a golden arm,” Harrison has been donating plasma since he was 18 years old. Now in his late seventies, he is still giving his lifesaving plasma to people who need it the most.

As a result, he had achieved a new milestone— on May 2011, he made his 1,000th donation.

That is not the only thing Harrison— and the whole world— can be proud of. Since his first donation in 1955, he has been giving a rare tonic of blood plasma that was eventually used to create and develop a vaccine. This is now known (and sold) as Rho(D) immune globulin, which has saved more than 2 million newborn babies’ lives.

Rho(D) immune globulin is a real lifesaving vaccine, but it is only efficient when prepared with blood from a donor who has rare antibodies in plasma, like Harrison. Because of this, he can still be seen donating blood every seven to ten days.

Peter Ray

An Australian war veteran, Ray just made his 800th blood donation on August 2012.

He started donating blood when he was just a 16 year-old apprentice in the Navy, and every two weeks, he donates plasma at Perth Blood Donor Centre.

Adding to his achievements is the fact that Ray is one of the 36 West Australian donors whose plasma is used to create Anti-D, which is a very special product that aids in preventing a disease known to newborn babies as Haemolytic Disease.

Terry George Price

A security guard from Denton, Texas, Price’s eyes are set on winning the Guinness World Records title for blood donation-aphaeresis.

Sixty years old and still going, Price has been donating to BioLife Plasma for a long time.  He has donated 1,000 times since his first time on May 2001, and has given 887.73 liters of plasma. While admitting that he is doing it for the money, he said that he stayed loyal because he is helping other people, as well.



Like the plasma heroes mentioned in this article— and many more— you, too, can become a one-of-a-kind hero.

Donate your plasma and make a difference!

Whole Blood Donation Records: Facts and Stories

Blood donation has proven its importance since the very first blood transfusion in 1665, when Richard Lower, a physician, saved a dog’s life with the use of other dogs’ blood. Since then, advancements and new knowledge in the process of blood donation has been discovered. Now, almost all of us know that just one or two pints of blood could go a long, long way— from aiding blood loss to saving lives.

Indeed, the process of blood donation is considered as one of the most vital activities in the society. That is why it is no wonder that people of all ages come to blood banks and participate in blood donation every single year. These people have been sharing their blood for various reasons— some like to donate because they want to help those who are in need, while others do it for their loved ones.

Are you curious as to how many people donate blood every year? Do you want to know who, among these people, reached— or even surpassed— their own blood donation goals? If your answer to both questions is a big, resounding “YES,” then read on and find out who might be helping those who need blood.


According to the American Red Cross, the estimated number of people who donate blood in the United States every year is 9.2 million, whereas the amount of blood donations collected in a year is 15.7 million.

Unfortunately, the phrase “there is not enough blood in this world” still applies even with that large number of donors and donations. Actually, those 9.2 million American donors still do not make the cut. Only less than 10% of the estimated 38% eligible US donors give blood every year, a percentage which is not enough to fill the needs of hospitals and blood banks every day, which amounts to more than 41,000 blood donations.

That “less than 10%” is something to be grateful for, though, and it is such a great blessing to have donors who are willing to share their blood to others. The nation might still be suffering from blood shortage from time to time, but luckily, there are kind and compassionate people who donate blood more than once in their lives. And, considering that even just a pint can save up to three lives, having few donors is ten times better than having no donors at all.


It is already a wonderful thing to donate blood even just once. Nothing beats the feeling of satisfaction and selflessness that blood donation could give you. But, can you imagine doing it, constantly, for many years?

The following people have proven that blood donation need not to be burden at all. These men started donating at a young age, and as the years passed, they did not regret nor stop what they were doing. They just kept going and going… until they have reached an amazing amount of donated blood that could inspire and motivate millions of people, from beginner donors to mere spectators.

Read their stories and be driven to do the same thing:

Michel Thérien

Since he was 18 years old, Michel has been donating blood for those who need blood the most. Every week for so many years, he has given blood at the globule Blood Donor Centre, in Centre Laurier Québec.  In 2009, he took a big leap for his fellow Canadians by giving blood for the 1,000th time.

This momentous event was a first for Canada, and because of his long service as a blood donor, Michel was awarded by Héma-Québec, one of Canada’s non-profit blood banks, with a medal that serves as the institution’s— and the country’s— sincerest and visible gratitude.

An engineer by profession, Michel does not intend to stop at his 1,000th mark. “As a donor, I have the power to make a huge impact on the lives of patients,” he said. “There is no price tag on that and I call on everyone to do the same… one donation at a time.”

Phil Baird

In 2010, Australian citizen Phil Baird became the world record holder for most whole blood donations. He set a new record when he donated for the 231st time at the Australian Red Cross Blood Service.

Starting out when he was just 19 years old, enlisting with the National Service, Phil has been donating blood ever since. “I have been told that I have donated more blood than is in the whole human body,” he said. True enough, he has donated a cumulative amount of 103.96 liters of blood, which is already considered many by all standards.

On Christmas Eve, he made his 231st whole blood donation, which surpassed the previous record of Robert Hall from New Zealand, who made a total of 177 blood donations.

John Sheppard

On July 2011, John Sheppard of Fort Myers, Florida, donated his 315th pint of blood, making him a new world record holder.

John started donating blood in 1951, when his friend, a badly-wounded soldier from the Korean War, needed blood in order to live. Since then, he has been donating blood every two months, eventually giving almost 40 gallons of blood.

A retired attorney, John was happy to be a record holder, but most of all, a lifesaver. “I hope the record will inspire others to donate blood,” he said.

Peter Ray

A war veteran, Australian citizen Peter Ray gave his 800th blood donation in August 2012, making him a record holder in Western Australia.

Peter started donating blood when he was only a 16 year-old Naval apprentice. Since then, he has been giving blood whenever he could, and eventually, he was able to help more than 2,400 lives.

He also donates plasma every two weeks, at Perth Blood Donation Center.

Matt Murphy

A simple Westminister man from Orange County, Matt made himself a living proof that good men exist when he made his 1,000th blood donation on June 2014.

Matt started giving blood— mostly platelets— 36 years ago, when he was still in college. Since then, he has been donating blood continuously, every time he could.

His 1,000th donation also came in a perfect time, since people have gone on their own vacations when Matt made his thousandth donation. His contribution filled in for the slight dip that the Red Cross experienced because of the vacation.


Every two seconds, someone in the US needs blood. This is why blood donation should not stop with just one pint.

Giving blood is a noble act, and even though it is not rewarding in a monetary fashion, the fact that someone lives when you donate blood is a great feeling.  Let these records and stories serve as your guide, should you consider donating blood yourself.

What Does AB+ Blood Type Say About You?


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AB Positive(+) blood type consists of both A and B antigens on red cells, but neither A nor B antibody in the plasma. This AB positive blood type makes you a universal plasma donor.

Personality Types     

The personalities of persons having this type AB Positive blood type are cool, controlled, rational and adaptable but critical, indecisive, forgetful and irresponsible. Mostly gentle and emotionally sensitive in ways, very empathetic and careful when dealing with others, and sometimes perceived to be having two personalities because they keep their true selves hidden from strangers.

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With type AB Positive blood, 82 percent more likely to have cognitive difficulties specifically in areas such as memory recall, language and attention compare to other blood types. The researchers shows that the clotting protein known as “coagulation factor VIII” is the reason behind of this.

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Famous Personalities with AB+ Blood Type

The famous people belong to this blood type are Thomas Edison, Bob Sapp, Miyavi, Jackie Chan, and Ken Kitamura. These people maybe shy and outgoing, and hesitant but confident. They stand out from others, practically nice and easy going. These people can only receive red cells from AB+, AB-, B+, B-, A+, A-, O+, O- blood types and can receive plasma only from A and B blood types.Jackie Chan_320x240

Diet for This AB+ Blood Type

Blood type AB Positive do best when their muscle tissues are slightly alkaline, it means that it can’t metabolize food easily due to low stomach acid. It is advise to importantly watch the portion size and frequency of eating meat and chicken. Tofu is a good protein supplements same with nuts, seeds, beans and legumes. This blood type is good on grains and even wheat. Remember, this blood type has a weaker immune system, so eat more high in phytochemicals vegetables and the more alkaline fruits.Miyavi_320x182

People with AB Positive blood type have been found to have a 23 percent increased risk of heart disease when compared to O blood type. This may cause to a pregnant mother to suffer from the blood pressure condition called pre-eclampsia.

The Universal Blood Donor: O Negative (O-) Blood Type

What Exactly is Type O-?

Each year, almost 5 million people are in need of transfusion from O Negative (O-) blood type donors in the United States. This type contains none of the three antigens such as A, B and Rh, which are antigens present in the red blood cells that help our immune system.

Donor to All, Recipient To One

This means that Type O- people are universal donors, but not universal recipients. It is the fourth rarest blood type, which only makes up approximately 9% of the population on earth.

Type O- people can give blood to anyone, but unfortunately, they can only receive blood from Type O- people too. Still, they’re a big help, especially in emergency situations where blood needs to be transfused immediately.

Personalities of O- Blood Type

Blood types are sometimes helpful in knowing someone’s trait, mindset and their level of compatibility with others. Here are Type O-s’ positive and negative traits:

Good Ones

People who have O Negative (O-) blood type are born leaders, independent, confident, have high determination in life, very competent and intuitive.

Not-So-Good Ones

Type Os are also unpredictable, very doubtful, egocentric and indifferent.

Famous Individuals with O- Blood Type

Here are the following individuals who have this O Negative (O-) blood type.

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  • Kurt Cobain
  • Elvis Presley
  • Erich Von Daniken
  • Senator John McCain
  • Charlie Chaplin
  • Former President Dwight Eisenhower
  • Jimi Hendrix
  • Paul Newman
  • Brad Steiger
  • John Lennon
  • Sting (Gordon Summer)
  • Peter Steele
  • Queen Elizabeth II
  • Liam Gallagher
  • Noel Gallagher
  • Prince Charles
  • Phil Collins
  • Matt Damon

Right Diet for O- Blood Type

Eating right for your blood type is important. It will help you decrease your chance of having diseases triggered by your bad eating habit.

For Type O- people, the high protein and lean meat diet is recommended.

Avoid the following, for they aid in gaining weight and have gluten, which causes stress on metabolism:

  • wheat
  • legumes
  • grains

Lactose intolerant people with Type O- blood should avoid:

  • milk
  • eggs

And replace them with the following instead:

  • soy milk
  • soy cheese


Learn more about blood types and how to donate blood by visiting our page at